NEURODEGENERATION

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Neurodegenerative diseases all share a common problem, proteins accumulate in the brain. We have found that an environmental neurotoxin can trigger two kinds of protein build up known as brain tangles and amyloid plaques.

This toxin links us directly to Alzheimer’s disease, Amyotrophic lateral sclerosis, Parkinson’s diseaseProgressive supranuclear palsy (PSP)Lewy body dementiaFrontotemporal dementia, and Pick’s disease.

We discovered that BMAA (beta-N-methylamino-l-alanine), a potent neurotoxin, is produced by cyanobacteria in the roots of the cycad trees of Guam. Through various pathways,  BMAA enters the traditional diet of the Chamorro people of Guam. These villagers suffer one of the highest rates of an ALS-like disease in the world. In a blinded study, we found BMAA in brain tissues of Chamorros who died of ALS/PDC but not in brain tissues of healthy control patients. We have also isolated BMAA from the brain tissues of ALS and Alzheimer’s patients from North America, but not in healthy controls. Our findings were replicated by the University of Miami Department of Neurology.

Through collaborative studies with Drs. Ken Rodgers and Rachael Dunlop in Sydney, Australia, we found that BMAA mimics the amino acid L-serine and inserts itself into neuroproteins, causing them to misfold and tangle. In both in vitro and in vivo studies we found that increasing L-serine can prevent BMAA misincorporation and resultant protein misfolding.

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