Multiple Sclerosis, About

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About Multiple Sclerosis

MS is thought to be an autoimmune disease that causes the body’s immune system to attack the protective coating (myelin) around nerve fibres in the central nervous system. These attacks cause inflammation often damaging the myelin in patches (known as demyelination). Myelin is needed for the smooth and rapid transmission of nerve impulses to and from the brain and spinal cord. Demyelination may cause scarring in the central nervous system resulting in interference in communication between the brain, spinal cord and other parts of the body. Depending on where the damage is, MS can affect different aspects of a person’s physical and cognitive functioning.

What are the symptoms?

People with MS may experience a wide range of symptoms throughout the course of the disease. Symptoms of MS can include: visual loss, limb weakness, poor balance, difficulty walking, chronic pain, bladder and/or bowel dysfunction, fatigue, numbness, tremors and depression. Cognitive dysfunction affects about half of all people living with MS. People with cognitive dysfunction typically experience difficulties with short-term memory, processing information speed, problem-solving, recalling words and planning and carrying out an activity. Visual spatial disorientation is also a common feature of this disease.

MS is divided into several basic categories, depending on the pattern of the individual’s disease. Approximately 85% of people are diagnosed with relapsing remitting MS (RRMS), characterized by unpredictable but clearly defined periods during which symptoms are apparent (relapse). Relapses can last for varying periods (from a few days to several months) and are followed by periods of recovery (remission) during which many functions return. With time, about half of those with RRMS may evolve into a secondary progressive phase of the disease, in which relapses and remissions no longer occur but develop gradual worsening of physical disability. Individuals who accumulate disability and experience worsening of symptoms right from the start are diagnosed with primary progressive MS. About 5% of people are diagnosed with progressive relapsing MS. People with this form of MS experience relapses with or without recovery and experience steadily worsening disease from the beginning.

How is multiple sclerosis diagnosed?

Diagnosing MS can be challenging as there is no single test to make the diagnosis. Physicians will assess patterns and types of symptoms along with a complete medical history and neurological examination to help make the diagnosis.

Brain imaging (MRI) is often used to detect any damage to the brain and spinal cord. A diagnosis of MS must include evidence of disease activity separated in time (lesions that formed at different points in time) and space (lesions in at least two separate areas of the CNS). The diagnosis of MS is made once other potential causes have been ruled out. Special tests may help to identify any abnormalities in the brain that are associated with MS. A spinal tap (lumbar puncture) may help to identify the presence of a specific protein found in the cerebrospinal fluid known to be present in MS. A spinal tap can also help to rule out other conditions. An evoked potential test may be used to assess the rate of electrical impulses produced in a person’s nervous system in response to stimuli.




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